Methylation-based deconvolution of cell-free DNA
收藏NIAID Data Ecosystem2026-05-01 收录
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资源简介：
Plasma cell-free DNA (cfDNA) released mainly by dying cells preserves the epigenetic characteristics of its cellular origin and in the presence of cancer part of this may originate from tumour cells. Here we exploit methylation features to estimate tissue contribution to plasma cfDNA sample focused on multi-cancer typing. Our method uses a reference atlas of tissues specific methylation markers to estimate relative contribution of each reference entity in a cfDNA sample thereby aiding in identifying the tissue of origin of the cancer in a cfDNA sample.EGA study EGAS00001007493
创建时间：
2023-09-21
