Polymorphism in microRNAs and their TargetSites

PolymiRTS (Polymorphism in microRNAs and their TargetSites) is a database of naturally occurring DNA variations in microRNA (miRNA) seed regions and miRNA target sites. MicroRNAs pair to the transcripts of protein-coding genes and cause translational repression or mRNA destabilization. SNPs and INDELs in miRNAs and their target sites may affect miRNA-mRNA interaction, and hence affect miRNA-mediated gene repression.PolymiRTS（微小RNA及其靶位点多态性数据库，Polymorphism in microRNAs and their TargetSites）是一个收录微小RNA（microRNA，miRNA）种子区及miRNA靶位点内天然DNA变异的数据库。微RNA可与编码蛋白质基因的转录本互补结合，引发翻译抑制或mRNA稳定性降低。微小RNA及其靶位点内的单核苷酸多态性（Single Nucleotide Polymorphism，SNP）与插入缺失（Insertion-Deletion，INDEL）可能影响miRNA与mRNA的相互作用，进而影响miRNA介导的基因抑制。

搜集汇总

背景与挑战

背景概述

PolymiRTS是一个专门收录microRNA种子区域及其靶位点自然DNA变异的数据库。这些变异如SNPs和INDELs可能干扰microRNA与mRNA的相互作用，从而影响microRNA介导的基因抑制过程。