Nickel-Catalyzed Directed C6-Selective C–H Alkylation of 2‑Pyridones with Dienes and Activated Alkenes
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资源简介：
A pyridine-directed, C6-selective nickel-catalyzed ring-contracting C–H alkylation of 2-pyridones with 1,5-cyclooctadiene (cod) has been developed. The reaction proceeds smoothly under external-ligand-free conditions and is accelerated uniquely by a K3PO4 base. Preliminary mechanistic investigations with deuterium-labeled substrates and related reactions with some alkenes are also disclosed.
创建时间：
2017-05-08
