Penetrating ballistic brain injury produces acute alterations in sleep and circadian-related genes in the rodent cortex: A preliminary study

We performed transcriptional profiling in an established rodent model of penetrating ballistic brain injury (PBBI) in conjunction with continuous sleep pattern recording of the first 24 hours after injury. 12 adult male Sprague-Daley rats that were randomized to PBBI (n=6) or sham (n=6) groups, animals received a right unilateral frontal PBBI, then were sacrificed after 24 hours of EGG/EMG recording. Brains were harvested, underwent sectioning and cortical tissue samples were stored. RNA were isolated from tissue samples. Overall design: RNA-seq of rats after 24 hours: sham and penetrating ballistic brain injury. This dataset includes samples from 11 mice (PBBI (n=6), sham (n=5)).