Selected genes with drug exposure-related, differential expression in liver in the subchronic experiment.

Data are given as fold change relative to vehicle, and presented as mean±SEM. Data shown are normalised to P0 (Arbp), with comparable results when normalised to β-actin. *P≤0.05 vs vehicle. **P≤0.01 vs vehicle. ***P≤0.001 vs vehicle. Subchronic data for the VEH, OLZ, and APZ groups have been reported in a previous article [23]. Gene abbreviations: Scd1; stearoyl-CoA desaturase. Fasn; fatty acid synthase. Srebp1; sterol regulatory element binding protein 1, Srebp2; sterol regulatory element binding protein 2. Hmgcr; 3-hydroxy-3-methylglutaryl-CoA reductase. Ppara: peroxisome proliferator activated receptor α, Pparg: peroxisome proliferator activated receptor γ. Cpt2: carnitine O-palmitoyltransferase 2. Acox1: acyl-Coenzyme A oxidase 1.