Expression data from endometrial adenocarcinoma cell line ISK with and without EZH2 knockdown

The findings indicate that EZH2 may act as a important therapeutic target for treatment of EAC. Furherly, EZH2 knockdown couldinduce G2/M phase arrest and resulted in cell proliferation inhibition. To further investigate how EZH2 overexpression impacted cell proliferation of EAC, Microarray gene expression profiling was performed on ISK cell line with or without EZH2 knockdown. Microarray gene expression profiling was performed on ISK cell line with and without EZH2 knockdown. Stable Scr and EZH2 knockdown cell lines were selected for RNA extraction and hybridization on Affymetrix microarrays. To that end, we prepared 3 biological duplication of Scr and EZH2 knockdown cell lines respectively.