ADAMTS3

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]

本基因编码ADAMTS（一种具有血栓生成素基序的金属蛋白酶和丝氨酸蛋白酶）蛋白家族的成员。该家族成员共享多个独特的蛋白模块，包括前肽区、金属蛋白酶结构域、类似解整合素结构域和血栓生成素1型（TS）基序。该家族的各个成员在C端TS基序的数量上存在差异，且某些成员具有独特的C端结构域。编码的前体蛋白经过蛋白酶解加工，生成成熟的蛋白酶。此蛋白酶属于蛋白聚糖胺基前肽酶蛋白亚家族，可能在关节软骨中II型原纤维状胶原蛋白的加工过程中发挥重要作用。[由RefSeq提供，2016年2月]