Transcriptome sequencing reveals expression characteristics of osteosarcoma before and after neoadjuvant chemotherapy

Osteosarcoma is the most common primary bone cancer in children, adolescents and young adults. It is a rare cancer type. To comprehensively reveal the transcriptomic characteristics of osteosarcoma before and after neoadjuvant chemotherapy (NACT), we performed next-generation sequencing (NGS) on 5 osteosarcoma patients undergoing NACT. Overall design: To comprehensively reveal the transcriptomic characteristics of osteosarcoma before and after NACT, matched osteosarcoma samples before and after NACT from five patients were sequenced using NGS.