Regulator of G protein signaling contributes to the development and aflatoxin biosynthesis in Aspergillus flavus through the regulation of Gα activity.

purpose: to further gain insight into the effect of RGS proteins on aflatoxin biosynthesis in A. flavus NRRL3357. methods: two mutants ΔrgsA and ΔrgsE separately compared to WT were chose to conduct the analysis of transcriptomics. results: 1750 DEGs are found, including 720 upregulated genes and 1030 downregulated genes in (ΔrgsA vs WT); aflB, aflD, aflF, aflG, aflN, aflP, aflS from ΔrgsE were transcriptionally reduced relative to ΔrgsA in their expressions. mRNA profiles of wild type (WT), ΔrgsA and ΔrgsE.