m6A profiling of hippocampus in TBI rats with hypothermia treatment

Recent studies have suggested a role for N6-methyladenosine (m6A) modification in neurological diseases. Hypothermia, as a commonly used treatment for traumatic brain injury, may plays a neuroprotective role by altering N6-methyladenosine (m6A) modifications. In this study, methylated RNA immunoprecipitation sequencing (MeRIP-Seq) was applied to conduct a genome-wide analysis of RNA m6A methylation in rat hippocampus of traumatic brain injury (TBI) and Post-TBI hypothermia treatment. In addition, we identified the expression of mRNA after TBI.