Dataset from SJTRC-St. Jude Tracking of Viral and Host Factors Associated With COVID-19: A Prospective Adaptive Cohort Study

This is a prospective adaptive cohort study of St. Jude employees to determine the rate of
SARS-CoV-2 infections that are asymptomatic and to evaluate immunological responses to
SARS-CoV-2 infection.

Primary Objectives

- To estimate the proportion of asymptomatic infection with SARS-CoV-2 infection in a
population of SARS-CoV-2-naïve adult St. Jude employees

- To comprehensively map CD4 and CD8 T cell epitopes and response magnitudes to SARS-CoV-2
infection in a population of SARS-CoV-2-naïve adult St. Jude employees who acquire
SARS-CoV-2 infection

- To measure changes in the CD4 and CD8 response magnitude and function to SARS-CoV-2
infection and/or vaccination in a population of St. Jude employees for up to 48 months
after infection and/or vaccination.

Secondary Objectives

- To establish seroprevalence of SARS-CoV-2-specific antibodies at baseline, and identify
the rate of seroconversion to SARS-CoV-2 in a population of presumably naïve adult St.
Jude employees

- To identify features of T cell responses at baseline and during SARS-CoV-2 infection
that are associated with protection against symptomatic or severe COVID-19 disease in a
population of adult St. Jude employees

- To identify risk factors for long-term protection against COVID-19 in a population of
adult St. Jude employees

- To evaluate changes in antibody responses to SARS-CoV-2 in a population of St. Jude
employees for up to 48 months after SARS-CoV-2 infection and/or vaccination.

- To evaluate the saliva antibody and cytokine response to SARS-CoV-2 infection and/or
vaccination and identify characteristics that predict protection from subsequent
SARS-CoV-2 infection among a population of St. Jude employees followed for up to 48
months after SARS-CoV-2 infection and/or vaccination.

- To measure changes in saliva antibody responses to SARS-CoV-2 for up to 48 months after
SARS-CoV-2 infection and/or vaccination.

Exploratory Objectives

- To establish additional immunological features including host immune or receptor
polymorphisms associated with response to SARS-CoV-2 infection

- To explore SARS-CoV-2 diversity and specific features in a circumscribed population

- To describe the presence, characteristics, and proportion of short-term re-infection

- To determine if an association between SARS-CoV-2 viral load in nasal swab specimens and
COVID-19 symptoms can be identified in a population of adult St. Jude employees who
acquire SARS-CoV-2

- To explore the laboratory and clinical response to SARS-CoV-2 vaccine in a population of
adult St. Jude employees with and without a history of SARS-CoV-2 infection