Exome sequencing of liver tissues of AID transgenic mice administered with thioacetamide. Mus musculus

Chronic inflammation triggers expression of a DNA mutator enzyme, activation-induced cytidine deaminase (AID), and induces tumorigenesis through mutation accumulation. To gain further insight into the inflammation-mediated genotoxic events required for carcinogenesis, we administered low-dose thioacetamide to AID transgenic mice, and performed exome sequencing of their cancerous or non-cancerous liver tissues.