Enterobacter hormaechei strain:BW Genome sequencing. Enterobacter hormaechei strain:BW

This whole genome sequencing project involves a patient who had a reoccurring Enterobacter hormaechei bacteremia. The infection spanned about 10 months, from the onset of the infection to the death of the patient. During that time, the infection evolved resistance to the multiple antibiotics used to treat it, including the very important class of carbapenems. Bacterial isolates with progressively higher levels of resistance were drawn from the patient at different time points. Later, these isolates were sequenced in order to identify the genetic determinants of the resistance. While all the isolates were sequenced on an Illumina platform, the last isolate to be drawn from the patient, called 56, was also sequenced on a PacBio platform. Because both PacBio and Illumina reads were available, the de novo assembly of the reads from 56 yielded a complete ungapped genomic sequence, consisting of a chromosome and two plasmids.