Supplementary tables: Gastrointestinal manifestations in pediatric and adult patients with Rett syndrome: an analysis of US claims and physician survey data

These are peer-reviewed supplementary tables for the article 'Gastrointestinal manifestations in pediatric and adult patients with Rett syndrome: an analysis of US claims and physician survey data' published in the Journal of Comparative Effectiveness Research.Supplementary Table 1: ICD-10-CM Codes for GI ManifestationsSupplementary Table 2: CPT Codes for MECP2 Genetic TestingSupplementary Table 3: ICD-10-CM Codes for Quan-Charlson Comorbidity IndexSupplementary Table 4: ICD-10-CM Codes for Differential Diagnosis of RTTAim: Patients with Rett syndrome (RTT) experience gastrointestinal (GI) manifestations. This study aimed to describe the prevalence of GI manifestations and the associated medical costs in patients with RTT in the USA. Patients & Methods: The study combined an insurance claims database analysis with a survey of 100 physicians experienced in RTT management. Results: GI manifestations affected 43.0% of 5940 patients, with increased prevalence in pediatric patients (45.6%) relative to adult patients (40.2%). Annualized mean medical cost of managing GI manifestations was $4473. Only 5.9–8.2% of neurologists and pediatricians ranked GI symptom management among the five most important treatment goals. Conclusion: Patients with RTT experience a high burden of GI manifestations, which translate to considerable medical costs. Importantly, the prevalence of GI manifestations was likely underestimated in this study, as only those symptoms which resulted in a healthcare encounter were captured.

本数据集为发表于《比较疗效研究杂志》的论文《Rett 综合征在儿童和成人患者中的胃肠道表现：美国索赔数据和医师调查数据的分析》的同行评审补充表格。补充表1：胃肠道表现的ICD-10-CM编码；补充表2：MECP2 基因检测的CPT编码；补充表3：Quan-Charlson 并发症指数的ICD-10-CM编码；补充表4：RTTA的鉴别诊断的ICD-10-CM编码。研究目的：Rett 综合征（RTT）患者存在胃肠道（GI）表现。本研究旨在描述美国RTT患者中胃肠道表现的普遍性和相关的医疗费用。研究对象与方法：研究结合了保险索赔数据库分析和100名具有RTT管理经验的医师的调查。研究结果：胃肠道表现影响了5940名患者中的43.0%，在儿童患者中的发生率（45.6%）高于成人患者（40.2%）。管理胃肠道表现的年度平均医疗费用为4473美元。仅有5.9%-8.2%的神经科医师和儿科医师将胃肠道症状管理列为五个最重要的治疗目标之一。研究结论：RTT患者承受着较高的胃肠道表现负担，这转化为相当可观的医疗费用。值得注意的是，本研究中胃肠道表现的普遍性可能被低估，因为仅捕获了导致医疗接触的症状。