Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound 7i

Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound 7i Descriptor: 1-(3-azanyl-1~{H}-1,2,4-triazol-5-yl)-~{N}-[2-(4-chlorophenyl)ethyl]-~{N}-(phenylmethyl)piperidin-4-amine, Chitotriosidase-1, GLYCEROL Authors: Mazur, M, Olczak, J, Olejniczak, S, Koralewski, R, Czestkowski, W, Jedrzejczak, A, Golab, J, Dzwonek, K, Dymek, B, Sklepkiewicz, P, Zagozdzon, A, Noonan, T, Mahboubi, K, Conway, B, Sheeler, R, Beckett, P, Hungerford, W.M, Podjarny, A, Mitschler, A, Cousido-Siah, A, Fadel, F, Golebiowski, A. Deposit date: 2017-04-22 Release date: 2018-03-28 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (1.447 Å) Cite: Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma. J. Med. Chem., 61, 2018