DNA-protein interactions play pivotal roles in many cellular activities, such as replication, development, and DNA repair. Here we report a DNB-based on-chip Motif Finding (DocMF) system that utilizes

DataCite Commons2021-05-08 更新40

Identification and characterization of a human MORC2 DNA binding region that is required for gene silencing. Identification and characterization of a human MORC2 DNA binding region that is required for gene silencing

表观遗传调控

蛋白质-DNA互作

The eukaryotic microrchidia (MORC) protein family are DNA gyrase, Hsp90, histidine kinase, MutL (GHKL)-type ATPases involved in gene expression regulation and chromatin compaction. The molecular mecha

NIAID Data Ecosystem20

MOESM4 of Spermatid-specific linker histone HILS1 is a poor condenser of DNA and chromatin and preferentially associates with LINE-1 elements

精子发生

蛋白质-DNA互作

Additional file 4: Table S3. Chromosome-wise peak length of HILS1 peaks. Excel file represents the length of HILS1 peaks across the chromosomes confirming their broad nature

Figshare2018-08-02 更新80

CUT&RUN to map WT1 binding in M15 cell lines that are genome edited for the KTS isoforms.

基因编辑与功能验证

蛋白质-DNA互作

throughput profiling of WT1 in M15 mouse mesonephric cells and M15 genome edited for the KTS isoforms. The genome-edited lines were derived from the M15 cells by transfection and puromycin selection o

NIAID Data Ecosystem30