RNAseq of 76 samples from Uveal Melanoma tumors
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https://www.omicsdi.org/dataset/ega/EGAS00001002932
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资源简介：
Hotspot mutations in the spliceosome gene SF3B1 are reported in 20% of uveal melanomas. SF3B1 is involved in 3'-splice site (3'ss) recognition during RNA splicing; however, the molecular mechanisms of its mutation have remained unclear. Here we show, using RNA-Seq analyses of uveal melanoma, that the SF3B1 R625/K666 mutation results in deregulated splicing at a subset of junctions, mostly by the use of alternative 3'ssEGA study EGAS00001002932
创建时间：
2018-11-09
