Two Cu(II) and Co(II)-based coordination polymers based on the N,S-mixed donor ligand: structural characterization and anti-endometrial cancer activity
收藏DataCite Commons2024-02-07 更新2024-07-28 收录
下载链接：
https://tandf.figshare.com/articles/dataset/Two_Cu_II_and_Co_II_-based_coordination_polymers_based_on_the_N_S-mixed_donor_ligand_structural_characterization_and_anti-endometrial_cancer_activity/12130425/1
下载链接
链接失效反馈官方服务：
资源简介：
In this study, two new coordination polymers based on Cu(II) and Co(II) ions as the metal nodes, {Cu(3-PPT)<sub>2</sub>]·H<sub>2</sub>O}<sub>n</sub> (<b>1</b>) and {[Co(3-PPT)<sub>2</sub>]·3CH<sub>3</sub>OH·H<sub>2</sub>O}<sub>n</sub> (<b>2</b>), have been successfully constructed from a pyridine-substituted N-heterocyclic thioamide ligand, namely 3-HPPT (3-HPPT = 4-(3-pyridinyl)-pyrimidine-2-thiol). Furthermore, the treatment activity of complexes <b>1–2</b> against HEC-1 endometrial cancer cells was evaluated. First, the CCK-8 assay was performed and the inhibitory effect of compounds <b>1–2</b> on HEC-1 cells were determined. Then, the Annexin V-FITC/PI method was performed and the induction activity of the compounds on the cancer cell apoptosis was evaluated. Finally, the PI3K/AKT pathway activation was also measured with western blot.
提供机构：
Taylor & Francis
创建时间：
2020-04-15
