Access to Polysubstituted (Furyl)methylthioethers via a Base-Promoted S‑H Insertion Reaction of Conjugated Enynones

A convenient
and applicable approach to the construction of diverse
functionalized (2-furyl)­methylthioether derivatives via base-promoted
S-H insertion of conjugated enynones with thiophenols or thiols has
been developed. This reaction features readily available starting
materials, high atom economy, broad substrate scope, and versatile
operation. Moreover, the synthetic utility of this method has been
demonstrated by the efficient synthesis of the CNKSPR1 inhibitor precursor
and late-stage functionalization of glutathione.