Access to Polysubstituted (Furyl)methylthioethers via a Base-Promoted S‑H Insertion Reaction of Conjugated Enynones

A convenient and applicable approach to the construction of diverse functionalized (2-furyl)­methylthioether derivatives via base-promoted S-H insertion of conjugated enynones with thiophenols or thiols has been developed. This reaction features readily available starting materials, high atom economy, broad substrate scope, and versatile operation. Moreover, the synthetic utility of this method has been demonstrated by the efficient synthesis of the CNKSPR1 inhibitor precursor and late-stage functionalization of glutathione.