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RNA Sequencing of Wild Type and SENP8+/- BMDM Transcriptomes after Treated with CD47-coated Beads

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE199585
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Neddylation is coupled with tumor-cell survival by its well-characterized substrates Cullins. However, how neddylation impacts the tumor immune microenvironment is not clear. SENP8 deconjugates NEDD8 from non-Cullin targets to maintain the dynamic and reversible neddylation equilibrium. CD47 treated SENP8+/+ and SENP8+/- BMDMs were detected to show impacted gene transcription. Relative mRNA level inCD47-liganded WT and SENP8+/- BMDMs.
创建时间:
2023-10-01
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