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Small molecule inhibitor of PRC1 E3 ligase activity induces differentiation of leukemia initiating cells [RNA-Seq]

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NIAID Data Ecosystem2026-03-12 收录
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We have developed small molecule inhibitors of PRC1. These inhibitors target PRC1, decrease H2A ubiquitination and differentiation of TEX cells. TEX cells treated with DMSO or 25uM WY332 compound for 6 days or 10 days and gene expression was profiled using RNA sequencing.

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2021-07-06
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