Potential treatments and interventions of HHL (Lu et al., 2023)

Purpose: The purpose of this study was to systematically review the research literature with regards to treatments and intervention methods for hereditary hearing loss. Our goal was to provide reference guidelines for the rational use of medication and gene-targeted therapy for patients with hereditary hearing loss and discuss the future development of research in this area.Method: We searched two core databases, PubMed and Web of Science, for relevant literature relating to potential treatments and interventional methods for hereditary hearing loss. Then, we used Microsoft Excel to perform basic statistical analysis of the data, the R language to perform bibliometric analyses, and VOSviewer and CiteSpace to visualize data. In addition, we clustered and descriptively analyzed the data and identified the relative importance of each approach with regard to precise patient outcomes.Results: In this study, we followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standardized screening process and identified a total of 103 research articles. The average annual growth rate of publications in this area was 12.73%. The country with the highest number of publications and citations was the United States; 80 of these publications (associated with 76.92% of funding) were supported by grants from 16 countries. Potential treatments and interventions were clustered according to the stage of research and showed that 8.74% remain in the research design stage, 59.22% are in the clinical validation stage, and 32.04% are being applied in the clinic. The main research focus in this field is cochlear implants and gene therapy.Conclusions: Hereditary hearing loss is in a critical period of transition from preventive to therapeutic research. Gene-targeted interventions represent one of the most promising and effective treatments.Supplemental Material S1. Search formulas and search time frames for each database.Supplemental Material S2. Ranking of authors with > 4 publications and articles fractionalized.Supplemental Material S3. Top 10 countries with average articles cited.Lu, Y., Hu, Y., Wang, S., Pan, S., An, K., Wang, T., He, Y., Tian, C., & Lei, J. (2023). Hereditary hearing loss: A systematic review of potential treatments and interventions. American Journal of Audiology. Advance online publication. https://doi.org/10.1044/2023_AJA-23-00069

研究目的：本研究的宗旨在于系统梳理与遗传性听力损失的治疗及干预方法相关的文献资料。我们的目标是为遗传性听力损失患者提供药物和基因靶向治疗的合理应用参考指南，并探讨该领域研究发展的未来趋势。研究方法：我们检索了PubMed和Web of Science两大核心数据库，收集与遗传性听力损失潜在治疗及干预方法相关的文献。随后，运用Microsoft Excel进行数据的基本统计分析，采用R语言执行文献计量分析，并利用VOSviewer和CiteSpace进行数据可视化。此外，我们对数据进行聚类和描述性分析，并确定了每种方法在精确患者结果方面的相对重要性。研究结果：在本研究中，我们遵循了系统评价和荟萃分析报告标准指南（PRISMA）的标准化筛选流程，共识别出103篇研究文章。该领域出版物平均年增长率为12.73%。在出版物和引用次数最多的国家中，美国位居首位；其中80篇（关联76.92%的资金）由来自16个国家的资助项目支持。潜在的治疗和干预措施根据研究阶段进行聚类，结果显示8.74%处于研究设计阶段，59.22%处于临床验证阶段，32.04%正在临床应用。该领域的主要研究焦点为耳蜗植入和基因治疗。研究结论：遗传性听力损失正处于从预防性研究向治疗性研究的过渡关键期。基因靶向干预措施代表了一种最有潜力和最有效的治疗方法。补充材料S1：各数据库的搜索公式和搜索时间范围。补充材料S2：发表4篇以上论文的作者排名及文章分数化。补充材料S3：平均引用次数最多的前10个国家。Lu, Y., Hu, Y., Wang, S., Pan, S., An, K., Wang, T., He, Y., Tian, C., & Lei, J. (2023). 遗传性听力损失：潜在治疗和干预的系统评价。美国听力学杂志。在线预发表。https://doi.org/10.1044/2023_AJA-23-00069