Bmp7
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1553810
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资源简介：
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Mutation of this gene results in skeletal, kidney, and other developmental defects. [provided by RefSeq, Jul 2016]
本基因编码TGF-β（转化生长因子-β）超家族蛋白的一种分泌型配体。该家族的配体与多种TGF-β受体结合，导致SMAD家族转录因子的募集和激活，进而调节基因表达。编码的前体蛋白经过蛋白水解加工，生成二硫键连接的同源二聚体的各个亚基。本基因的突变会导致骨骼、肾脏及其他发育缺陷。[由RefSeq提供，2016年7月]
提供机构：
Rat Genome Database
