Transcriptional profile of lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) tumors from KRasG12D; Fbw7f/f mice

We performed lung ADC and SCC transcriptome profiling from KRasG12D; Fbw7f/f murine lung tumors by RNA-seq and compared them with a consensus lung SCC signature using data from two different SCC models (Lkb1f/f; Ptenf/f, Cancer Cell 2014 and LSL-Sox2; Ptenf/f; Cdkn2abf/f, Cancer Cell 2016) that has been validated in human lung SCC Transcriptome profiles of lung adenocarcinoma and squamous cell carcinoma were generated by deep sequencing, in triplicate (primary tumors) or duplicate (primary cells).