Bis(bicyclo[1.1.1]pentyl)chlorophosphine as a Precursor for the Preparation of Bis(bicyclo[1.1.1]pentyl)phosphines

Dialkylchlorophosphines are among the most versatile
building blocks
for tertiary phosphine ligands, but their synthesis relies on the
nucleophilic substitution of PCl3, leaving substituents
that require P–H precursors largely inaccessible. The primary
phosphine reagent iPr2NPH2·BH3 can serve as a doubly protected PH2Cl proxy, enabling
the synthesis of bis(bicyclo[1.1.1]pentyl)chlorophosphine (Bcp2PCl) for the first time. Bcp2PCl serves as a general
reagent for the preparation of a family of bis(bicyclo[1.1.1]pentyl)
alkyl- and arylphosphines, including new members of privileged phosphine
ligand scaffolds.