HIV-2 group A IN polymorphisms.

Polymorphisms of the HIV-2 group A IN sequences from 63 treatment-naïve patients are reported with respect to the ROD reference sequence. The three different domains of IN are indicated: the N-terminal domain (AA 1–49); the catalytic core domain (AA 50–212) containing the conserved catalytic triad (DDE motif); and the C-terminal domain (AA 213–288). Positions known to confer resistance to INSTIs in HIV-1 or HIV-2 are marked with a star (*). The frequency (percentage) of each of each of the polymorphisms is indicated in brackets. Only positions where variations were detected are reported. Shannon's entropy at each variable position is indicated; an entropy value of 0 corresponds to an amino acid strictly conserved, and higher entropy values indicate more variability.