Structure of Cyclic Nucleoside Phosphonate Ester Prodrugs: An Inquiry
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https://figshare.com/articles/dataset/Structure_of_Cyclic_Nucleoside_Phosphonate_Ester_Prodrugs_An_Inquiry/2564947
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资源简介：
The configuration at phosphorus in cyclic (S)-HPMPC
(1, cidofovir) and (S)-HPMPA (2) phenyl ester (5 and 6, respectively)
diastereomers ((Rp)-5, (Rp)-6, (Sp)-6) was determined by X-ray crystallography and correlated
to their 1H and 31P NMR spectra in solution. (Rp)-5 and (Rp)-6 have chair conformations
with the nucleobase substituent equatorial and the P-OPh axial. Perhaps
surprisingly, (Sp)-6 is (a, a) in the crystal
and exists largely as an equilibrium of (a, a)/(e, e) conformers in
chloroform or acetonitrile.
创建时间：
2012-01-06
