Figure 7: in vivo Toxicity of Peptoid TM5 following intratracheal delivery

(A) BALB/c mice were treated with 50 µL of either 40 µg/mL (p) or 80 µg/mL (¡) doses of TM5 and monitored for survival at 0, 2, 4, 6, 8, 10, 24, 30, and 48 hours post-treatment (n = 2 mice per concentration). (B) BALB/c mice were treated with increasing doses of TM5 to determine a toxicity threshold and monitored for disease symptoms at 0, 2, 4, 6, 8, 10, 24, 30, and 48 hours post-treatment as indicated below the X-axis. Error bars represent SEM across n = 4 mice, and timepoints marked with an X indicated animals humanely euthanized at that timepoint.