Data From: Global huntingtin knockout in adult mice leads to fatal neurodegeneration that spares the pancreas

Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG tract in the Huntingtin (HTT) gene, leading to toxic gains of function. HTT-lowering treatments are in clinical trials but risks imposed are unclear. Recent studies have reported on the consequences of widespread HTT loss in mice, where one group described early HTT loss leading to fatal pancreatitis, but later loss as benign. Another group reported no pancreatitis but found widespread neurological phenotypes including subcortical calcification. To better understand the liabilities of widespread HTT loss we knocked out Htt with two separate tamoxifen-inducible Cre lines. We find that loss of HTT at 2 months of age leads to progressive tremors and severe subcortical calcification at examination at 14 months of age but does not result in acute pancreatitis or histological changes in the pancreas. We additionally report that HTT loss is followed by sustained induction of circulating neurofilament ligh..., Data and R scripts from the manuscript: Global huntingtin knockout in adult mice leads to fatal neurodegeneration that spares the pancreas (https://doi.org/10.26508/lsa.202402571), , # Data From: Replication Study: Adult-Onset, Global Huntingtin Knockout in Mice Leads to Fatal Progressive Neurodegeneration but not Pancreatic Pathology

[https://doi.org/10.5061/dryad.9zw3r22kt](https://doi.org/10.5061/dryad.9zw3r22kt)

Dataset and R scripts used to generate all statistics and figures for the associated manuscript are deposited here in the .xlsx file 'cKO manuscript rProject source data.xlsx'.

The .xlsx file comprises 17 separate worksheets with a leading number (e.g. 01b, 01c, etc) which indicates where the data was used in the manuscript, along with a short identifying text (e.g. Sentinel HTT) which gives additional context about what the data corresponds to. Each worksheet and it's column headings are defined below. 

Corresponding R scripts for analysis are also included. R scripts pull data from the .xlsx sheet and make plots and/or run statistics used in the manuscript and include basic annotation. R script naming follows the same convention as the data, for ex...