The effect of the interventions on hallmarks and complications of T2DM.

Body weight, epidydimal adipose tissue weight, fasting plasma concentrations of glucose, insulin, cholesterol and triglycerides (TG) of the experimental groups are shown together with the intrahepatic TG concentrations, the urinary albumin/creatinine ratio and the atherosclerotic lesion area. Data represent the effects of drug intervention or dietary lifestyle intervention (DLI) at 16 weeks, i.e. the end of study. One group was sacrificed earlier and prior to the start of the interventions at 9 weeks (HFD 9w). *P<0.05 compared to HFD 16w, #P<0.05 for within subject change from 9 weeks to 16 weeks compared to HFD. Data are shown as mean ± SEM.