Synthesis of Highly Substituted Imidazole Uracil Containing Molecules via Ugi-4CR and Passerini-3CR
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https://figshare.com/articles/dataset/Synthesis_of_Highly_Substituted_Imidazole_Uracil_Containing_Molecules_via_Ugi-4CR_and_Passerini-3CR/5925310
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资源简介：
The
synthesis of uracil/thymine containing tetra/trisubstituted
imidazole derivatives was demonstrated using Ugi/Passerini-reaction
followed by a postcyclization reaction sequence. The approach enables
the one-pot facile construction of diverse compounds in moderate to
excellent yields (47–82%). The 5-fluorouracil and 5-methyluracil
moieties afford potentially bioactive molecules with drug-like properties.
These scaffolds are currently being utilized in the screening deck
of the European Lead Factory.
创建时间：
2018-02-26
