Synthesis of chromeno[2,3-<i>b</i>]indeno[2,1-<i>e</i>]pyridine derivatives via K<sub>2</sub>CO<sub>3</sub>-promoted three-component reaction of 2-amino-4<i>H</i>-chromen-4-ones, aromatic aldehydes and 1<i>H</i>-Indene-1,3(2<i>H</i>)-dione
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An efficient process to access chromeno-fused azafluorenones (chromeno[2,3-<i>b</i>]indeno[2,1-<i>e</i>]pyridine) via the three-component reaction between 2-amino-4<i>H</i>-chromen-4-ones, aromatic aldehydes and 1<i>H</i>-indene-1,3(2<i>H</i>)-dione is described. This approach includes successive the Aldol condensation, the Michael addition, intramolecular nucleophilic addition and aromatization. The structure of a product obtained was determined based on X-ray diffraction studies. Chromeno[2,3-b]indeno[2,1-e]pyridine derivatives were synthesized effectively via a K<sub>2</sub>CO<sub>3</sub>-promoted three-component reaction of 2-amino-4H-chromen-4-ones, aromatic aldehydes and 1H-Indene-1,3(2H)-dione under mild conditions.
创建时间:
2023-05-22



