Translation of PPP1R15A

The PPP1R15A (GADD34) mRNA is translated to yield PPP1R15A protein which then associates with the cytosolic faces of the endoplasmic reticulum membrane and the mitochondrial outer membrane (inferred from the mouse homolog). The PPP1R15A mRNA contains 2 upstream ORFs (uORFs) that limit translation of the downstream PPP1R15A coding region (inferred from the mouse homolog). During certain stresses, EIF2S1 (eIF2-alpha) is phosphorylated, causing a reduction in initiation at the uORFs and increased translation of the PPP1R15A coding region (inferred from mouse homologs).

PPP1R15A（GADD34）mRNA被翻译成PPP1R15A蛋白，随后该蛋白与内质网膜胞质面和线粒体外膜（据小鼠同源物推断）相结合。PPP1R15A mRNA含有2个上游开放阅读框（uORFs），这些阅读框限制了下游PPP1R15A编码区域的翻译（据小鼠同源物推断）。在特定应激条件下，EIF2S1（eIF2-α）发生磷酸化，导致上游开放阅读框的起始翻译减少，而PPP1R15A编码区域的翻译增加（据小鼠同源物推断）。