Donor T-cell DNMT3a regulates alloreactivity in murine models of hematopoietic stem cell transplantation [WGBS]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE196541
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Donor T-cell methylation state has an effect on alloreactivity. We applied WGBS and the InformME analysis pipeline to investigate the role of DNA methylation in mice receiving transplantation from T-cell conditional DNMT3a KO donors. WGBS was carried out on DNA from purified donor splenic T-cells post-transplantation from WT or DNMT3a KO donors in models of GVHD. The InformME analytic pipeline was applied to these data.
创建时间:
2022-09-12



