Mettl3-mediated m6A Methylation Determines the Size of Endocrine Progenitor Pool and Postnatal Islet Mass [scRNA-seq]
收藏Alliance of Genome Resources2026-08-01 收录
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To investigate the role of RNA methyltransferase-like 3 (Mettl3)-mediated m6A modification in pancreatic endocrine differentiation in early embryonic period. We then performed single cell RNA-seq at E15.5 Mettl3pKO pancreas group and E15.5 WT pancreas group We generated transgenic mice lacking Mettl3 specifically in Pdx1+ pancreatic progenitor cells(Mettl3pKO) and dissect E15.5 Mettl3pKO and WT pancreata for single cell RNA-seq.
