Formal Total Synthesis of Actinoranone: Synthesis Approaches and Cytotoxic Studies

This article describes
our efforts toward the total synthesis of
actinoranone. Our synthesis strategies rely on a convergent route
to connect the terpenoid and polyketide fragments, employing catalysis
and powerful classical reactions for the assembly of these key fragments.
A new transformation was disclosed during this work, a domino ring-opening
and esterification. Initial cytotoxic studies for the selected synthesis
intermediates are also presented.