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Synthesis of Pyroglutamic Acid Derivatives via Double Michael Reactions of Alkynones

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https://figshare.com/articles/dataset/Synthesis_of_Pyroglutamic_Acid_Derivatives_via_Double_Michael_Reactions_of_Alkynones/3005776
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In the presence of substoichiometric quantities of potassium tert-butoxide and an additional metal salt, amide-tethered diacids undergo double Michael reactions with alkynones to provide highly functionalized pyroglutamic acid derivatives. The metal salt was found to play an important role in improving the diastereoselectivities of the reactions.
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2016-02-29
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