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Blood plasma lipidomics peak area data from 67 children with increased risk of type 1 diabetes and variable number of autoantibodies generated by targeted mass spectrometry

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Figshare2019-12-16 更新2026-04-08 收录
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This dataset consists of a single Excel xlsx file containing peak area data for 128 lipid species detected by mass spectrometry from 67 children with increased risk of type 1 diabetes and different number of autoantibodies. <br>Individuals studied herein are participants in the DiabetesPrediction in Skåne Study, a prospective population-based study, following children from birth with the aim to investigate genetic and environmental factors that may contribute to the development of T1D. All participants were 10-15 years of age at the time of sampling and were healthy (no diabetes) with or without autoantibodies. <br>Lipid extracts were analyzed using an ultra-high-performance liquid chromatography quadrupole time-of-flight mass spectrometer (UHPLC-Q-TOF-MS) operated in the positive ion mode. The column was an Acquity UPLC™ BEH C18 2.1×100 mm with 1.7 µm particles from Waters (Milford, CT, USA).<br>This dataset contains raw peak area data for 128 lipid species across 11 classes. These classes and their abbreviations as used in the dataset are as follows:<br>* cholesteryl ester (CE),* ceramide (Cer),* lysophosphatidylcholine (LPC),* phosphatidylcholine (PC),* alkylphosphatidylcholine (PC(O)),* alkenylphosphatidylcholine (plasmalogen, PC(P)),* phosphatidylethanolamine (PE),* alkylphosphatidylethanolamine (PE(O)),* phosphatidylethanolamine plasmalogen (PE(P)),* phosphatidylinositol (PI),* sphingomyelin (SM),* triacylglycerol (TG),<br>Further analysis and explanation of these data are presented in the accompanying manuscript.

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2019-12-16
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