Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue WIZ-6

Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue WIZ-6 Descriptor: (3S)-3-(5-{[(3R,6S)-1-ethyl-6-methylpiperidin-3-yl]oxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione, DNA damage-binding protein 1, Protein Wiz, ... Authors: Partridge, J.R, Ma, X, Ornelas, E. Deposit date: 2024-09-07 Release date: 2024-11-27 Last modified: 2024-12-11 Method: X-RAY DIFFRACTION (3.35 Å) Cite: Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease. J.Med.Chem., 67, 2024