RORγt -expressing FOXP3+ skin-resident Treg cells derived from the periphery in Allergen-Specific Immunotherapy

The study explored the impact of Specific Immunotherapy on patients with Atopic Dermatitis sensitized to house dust mites by analyzing the transcriptomes of T regulatory cells before and after treatment. Result found that effective SIT is associated with distinct gene expression changes in Treg cells, particularly increased expression of Treg markers and RORC, a gene linked to immune regulation. These results indicate that successful SIT may enhance the function of Treg cells expressed RORC and help restore immune balance in these patients. Patients with Atopic Dermatitis (AD) sensitized to house dust mites are divided into two groups based on their response to Specific Immunotherapy (SIT): those who showed an effective response (R) and those who did not respond (Non-R). Results identified differentially expressed genes before and after SIT in R and Non-R groups.