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Total Synthesis of Camptothecin and SN-38

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NIAID Data Ecosystem2026-03-07 收录
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https://figshare.com/articles/dataset/Total_Synthesis_of_Camptothecin_and_SN_38/2565076
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A new practical and concise total synthesis of enantiopure camptothecin and SN-38 (14% overall yield, 99.9% ee and 99.9% purity) was described, starting from inexpensive and readily available materials. The development of column chromatography-free purification was achieved in all steps, which offers an economic industrial process to the camptothecin-family alkaloids.
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2016-02-22
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