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Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa

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Protein Data Bank Japan2024-04-03 更新2026-03-21 收录
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Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa Descriptor: (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, (8S)-8-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-1,8-dihydro-2H-[1]benzopyrano[4,3-d][1]benzoxepine-5,11-diol, Estrogen receptor, ... Authors: Kiefer, J.R, Vinogradova, M, Liang, J, Zhang, B, Ortwine, D.F, Nettles, K.W, Nwachukwu, J.C. Deposit date: 2018-05-15 Release date: 2019-02-20 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorg. Med. Chem. Lett., 29, 2019
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2018-05-15
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