Experimental setup of the immunization mixtures and NTHi strains used in this study with respect to their relevance for the immune systems of the immunized mice.

aKnown and unknown refer to the presence or absence of the particular LOS or surface proteins in the immunization mixtures, respectively.bLOS group classification as previously published [19], [49].cAccording to the OMP subtype classification developed by Murphy et al. [46] and the heterologous protein profiles shown in Fig. 1.dStrains underlined were used for challenge.eNot determined by Murphy et al. [46].