Anti-proliferative activity of the examined agents in MCF-7 cells.
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The studied agents (chelators and their fully coordinated iron (Fe) or copper (Cu) complexes and anti-cancer agents) were incubated with MCF-7 cells for 72 h at 37°C. Cell viability was determined using the neutral red uptake assay and the IC50 values (the concentration inducing a 50% reduction in proliferation compared to the control) were calculated using CalcuSyn 2.0 software; n≥4 experiments. Statistical significance (ANOVA): *p<0.05, **p<0.01, ***p<0.001 as compared to the same uncomplexed chelator.
创建时间：
2014-02-20
