Epigenetic Drift of H3K27me3 in Aging Links Glycolysis to Healthy Longevity
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
下载链接：
http://data.iscr.ac.cn/Article?id=74f9d5b3530672b7747e7a285666a4bf
下载链接
链接失效反馈官方服务：
资源简介：
We adapted ChIP-Rx method established in cells to fly tissues for quantitative ChIP-seq. We found the deposition of H3K27me3 during aging loses fidelity, resulting its propagation across the epigenome; lowering H3K27me3 by PRCs-deficiency promotes healthy lifespan by mitigating this trend. Quantitative multi-omic analysis converges on a central role of glycolysis, linking H3K27me3 dynamics to the regulation of glycolytic genes, which correspondingly rewire cellular metabolic homeostasis including energy and redox potential that impact lifespan and adult fitness.
提供机构：
Chinese Academy of Science
创建时间：
2022-02-20
