Chromatin insulators are DNA-protein complexes situated throughout the genome that contribute to higher order organization and demarcation into distinct transcriptional domains. Mounting evidence in

NIAID Data Ecosystem50

Iron-sensitive RNA regulation by poly C binding proteins [DKD_RNASeq]

铁代谢调控

RNA结合蛋白功能

Iron is important for normal cellular function and posttranscriptional mechanisms regulate the cellular response to iron deficiency. In this study we explore how RNA binding proteins, PCBP1 and PCBP2,

NIAID Data Ecosystem20

RBP CELF2 regulates acute leukemia development via FAT10-mTORC1 [RIP-seq]

白血病分子机制

RNA结合蛋白功能

We demonstrated that CELF2 regulates FAT10, and promotes mTORC1 signaling pathway activation in MLL-AF9-AML mice. K562 cells with either expression of 3xflag-HA-CELF2 or empty vector were seeded in 10

NIAID Data Ecosystem60

Distinct, opposing functions for CFIm59 and CFIm68 in mRNA alternative polyadenylation of Pten and in the PI3K/Akt signalling cascade

选择性多聚腺苷酸化

PTEN信号通路

The precise maintenance of PTEN dosage is crucial for tumor suppression across a wide variety of cancers. Post-transcriptional regulation of Pten heavily relies on regulatory elements encoded by its 3

NIAID Data Ecosystem30