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Inhibiting Fungal Multidrug Resistance by Disrupting an Activator-Mediator Interaction With the Small Molecule iKIX1

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Eukaryotic transcription activators stimulate the expression of specific sets of target genes through recruitment of co-activators such as the RNA polymerase II-interacting Mediator complex

真核转录激活因子(Eukaryotic transcription activators)可通过招募共激活因子(co-activators),例如与RNA聚合酶II(RNA polymerase II)相互作用的中介体复合物(Mediator complex),来激活特定靶基因集合的表达。

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