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Sequential enhancer sequestration dysregulates recombination center formation at the IgH locus

NIAID Data Ecosystem2026-03-11 收录

V(D)J重组调控

B细胞发育

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE109631 数据链接链接失效反馈

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We reoprt that transcriptional level of distal VH is dependent of both intronic enhancer (Eµ) and intergenic control region 1 (IGCR1). Examination of total RNA from different Pro-B cell lines.

应用场景：

创建时间：

2019-03-25

染色质构象

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A multiscale 3D chromatin architecture that controls development of the humoral immune system is assembled by IKAROS [HiC_LpreB_Steadystate]. A multiscale 3D chromatin architecture that controls development of the humoral immune system is assembled by IKAROS [HiC_LpreB_Steadystate]

染色体三维结构

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A generic level of chromatin organization generated by the interplay between cohesin and CTCF suffices to limit promiscuous interactions between regulatory elements, but a lineage-specific assembly of

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Sequential enhancer sequestration dysregulates recombination center formation at the IgH locus

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