Urinary CFH levels were associated with renal outcome in the whole IgAN cohort.

Abbreviation: CI, confidence interval; uCFH, urinary complement factor H; uCr, urinary creatinine.Cox proportional hazard model was used to do the analyses. A composite endpoint was defined asESRD, ≥50%eGFR decline or doubling of serum creatinine levels. Urinary CFH levels wereshownas uCFH/uCr. uCFH/uCr values were used as continuous, dichotomous and quartile variables in the analyses.Adjusted models were set up as below.aModel 1 adjusted for eGFR, proteinuria, mean arterial blood pressure(MAP).bModel 2 adjusted for covariates in model 1 plus histological grades(mild and severe lesion groups).cModel 3 adjusted for covariates in model 2 plus prednisone and/or other immunosuppressive agents.Urinary CFH levels were associated with renal outcome in the whole IgAN cohort.